Meningeal lymphatics can influence stroke outcome

Gou Young Koh and Donald M. McDonald

Fibroblasts enable penile erection

Perivascular fibroblasts may underlie erectile dysfunction

Ki-Kan Ryu and Gou Young Koh

Nasopharyngeal lymphatic plexus is a hub for cerebrospinal fluid drainage

Jin-Hui Yoon, Hokyung Jin, Hae Jin Kim, Seon Pyo Hong, Myung Jin Yang, Ji Hoon Ahn, Young-Chan Kim, Jincheol Seo, Yongjeon Lee, Donald M. McDonald, Michael J. Davis & Gou Young Koh

This article is summarized and highlighted in Research Briefing, as titled "Drain ‘pipes’ behind the nose clear cerebrospinal fluid from the brain". Nature 2024


Immaturity of immune cells around the dural venous sinuses contributes to viral meningoencephalitis in neonates

Young-Chan Kim, Ji Hoon Ahn, Hokyung Jin, Myung Jin Yang, Seon Pyo Hong, Jin-Hui Yoon, Sang-Hoon Kim, Tirhas Niguse Gebre, Hyuek Jong Lee, You-Me Kim, Gou Young Koh

Endothelial cell-derived stem cell factor promotes lipid accumulation through c-Kit-mediated increase of lipogenic enzymes in brown adipocytes

Hyuek Jong Lee, Jueun Lee, Myung Jin Yang, Young-Chan Kim, Seon Pyo Hong, Jung Mo Kim, Geum-Sook Hwang, Gou Young Koh

Three-dimensional morphologic and molecular atlases of nasal vasculature

Seon Pyo Hong, Myung Jin Yang, Jung Hyun Bae, Du Ri Choi, Young-Chan Kim, Myeon-Sik Yang, Byungkwan Oh, Kyung Won Kang, Sang-Myeong Lee, Bumseok Kim, Yong-Dae Kim, Ji Hoon Ahn, Gou Young Koh

Highlighted in Research briefing - Distributions of venous sinusoids and lymphatic vessels in the mouse nasal cavity. Nature Cardiovascular Research (2023) 

Hyperactivation of YAP/TAZ drives alterations in mesangial cells through stabilization of N-MYC in diabetic nephropathy

Seunghyeok Choi, Seon Pyo Hong,  Jung Hyun Bae, Sang Heon Suh, Hosung Bae, Kyung Pyo Kang*, Hyuek Jong Lee, Gou Young Koh


Gatekeeping role of Nf2/Merlin in vascular tip EC induction through suppression of VEGFR2 internalization

Jung Hyun Bae, Myung Jin Yang, Seung-hwan Jeong, JungMo Kim, Seon Pyo Hong,  Jin Woo Kim, Yoo Hyung Kim, Gou Young Koh

Apelin drives maintenance and expansion of the vascular niche in intestinal crypts

Gou Young Koh

Viewpoints: Dual-blocking antibody against VEGF-A and angiopoietin-2 for treating vascular diseases of the eye

Gou Young Koh, Hellmut G. Augustin and Peter A. Campochiaro

Antiangiogenesis: Vessel regression, vessel normalization, or both?

Hellmut G. Augustin & Gou Young Koh


Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody

Gyunghee Jo, Jeomil Bae, Ho Jeong Hong, Ah-reum Han, Do-Kyun Kim, Seon Pyo Hong, Jung A Kim, Sangkyu Lee, Gou Young Koh & Ho Min Kim 

Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour

Seung-hwan Jeong, Myung Jin Yang, Seunghyeok Choi, JungMo Kim & Gou Young Koh 

Nasal ciliated cells are primary targets for SARS-CoV-2 replication in early stage of COVID-19

Ji Hoon Ahn, JungMo Kim, Seon Pyo Hong, Sung Yong Choi, Myung Jin Yang, Young Seok Ju, Young Tae Kim, Ho Min Kim, MD Tazikur Rahman, Man Ki Chung, Sang Duk Hong, Hosung Bae, Chang-Seop Lee & Gou Young Koh

Control of endothelial quiescence by FOXO-regulated metabolites

Jorge Andrade, Chenyue Shi, Ana S. H. Costa, Jeongwoon Choi, Jaeryung Kim, Anuradha Doddaballapur, Toshiya Sugino, Yu Ting Ong, Marco Castro, Barbara Zimmermann, Manuel Kaulich, Stefan Guenther, Kerstin Wilhelm, Yoshiaki Kubota, Thomas Braun, Gou Young Koh, Ana Rita Grosso, Christian Frezza & Michael Potente 


Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2

Jeonghwan Youk, Taewoo Kim, Kelly V. Evans, Young-Il Jeong, Yongsuk Hur, Seon Pyo Hong, Je Hyoung Kim, Kijong Yi, Su Yeon Kim, Kwon Joong Na, Thomas Bleazard, Ho Min Kim, Mick Fellows, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Seon Young Kim, Young Tae Kim, Gou Young Koh, Byeong-Sun Choi, Young Seok Ju & Joo-Hyeon Lee

Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi

Seon Pyo Hong, Myung Jin Yang, Hyunsoo Cho, Intae Park, Hosung Bae, Kibaek Choe, Sang Heon Suh, Ralf H. Adams, Kari Alitalo, Daesik Lim & Gou Young Koh

Biological functions of lymphatic vessels

Tatiana V. Petrova & Gou Young Koh

Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance

Hosung Bae, Ki Yong Hong, Choong-kun Lee, Cholsoon Jang, Seung-Jun Lee, Kibaek Choe, Stefan Offermanns, Yulong He, Hyuek Jong Lee & Gou Young Koh

YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells

Sung Yong Choi, Hosung Bae, Sun-Hye Jeong, Intae Park, Hyunsoo Cho, Seon Pyo Hong, Da-Hye Lee, Choong-kun Lee, Jin-Sung Park, Sang Heon Suh, Jeongwoon Choi, Myung Jin Yang, Jeon Yeob Jang, Lucas Onder, Jeong Hwan Moon, Han-Sin Jeong, Ralf H. Adams, Jin-Man Kim, Burkhard Ludewig, Joo-Hye Song, Dae-Sik Lim & Gou Young Koh 


Benefits and pitfalls of tumor vessel normalization

Jin-Sung Park, Intae Park & Gou Young Koh

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

Ji Hoon Ahn, Hyunsoo Cho, Jun-Hee Kim, Shin Heun Kim, Je-Seok Ham, Intae Park, Sang Heon Suh, Seon Pyo Hong, Joo-Hye Song, Young-Kwon Hong, Yong Jeong, Sung-Hong Park & Gou Young Koh

Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages

Sang Heon Suh, Kibaek Choe, Seon Pyo Hong, Seung-hwan Jeong, Taija Mäkinen, Kwang Soon Kim, Kari Alitalo, Charles D Surh, Gou Young Koh & Joo-Hye Song

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation

Choong-kun Lee, Seung-hwan Jeong, Cholsoon Jang, Hosung Bae, Yoo Hyung Kim, Intae Park, Sang Kyum Kim & Gou Young Koh

A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

Yoo Hyung Kim, Jeongwoon Choi, Myung Jin Yang, Seon Pyo Hong, Choong-kun Lee, Yoshiaki Kubota, Dae-Sik Lim & Gou Young Koh 

Tie2 activation promotes choriocapillary  regeneration for alleviating neovascular age-related macular degeneration

Jaeryung Kim, Jang Ryul Park, Jeongwoon Choi, Intae Park, Yoonha Hwang, Hosung Bae, Yongjoo Kim, WooJhon Choi, Jee Myung Yang, Sangyeul Han,  Tae-Young Chung, Pilhan Kim, Yoshiaki Kubota, Hellmut G. Augustin, Wang-Yuhl Oh & Gou Young Koh

YAP and TAZ negatively regulate Prox1 during developmental and pathologic lymphangiogenesis

Hyunsoo Cho, Jaeryung Kim, Ji Hoon Ahn, Young-Kwon Hong, Taija Mäkinen, Dae-Sik Lim & Gou Young Koh


Morphological analysis of lacteal structure in the small intestine of adult mice

Sang Heon Suh, Seon Pyo Hong, Intae Park, Joo-Hye Song & Gou Young Koh

Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

Seung-Jun Lee, Choong-kun Lee, Seok Kang, Intae Park, Yoo Hyung Kim, Seo Ki Kim, Seon Pyo Hong, Hosung Bae, Yulong He, Yoshiaki Kubota & Gou Young Koh

YAP/TAZ Initiates gastric tumorigenesis via upregulation of MYC

Wonyoung Choi, Jeongsik Kim, Jaeoh Park, Da-Hye Lee, Daehee Hwang, Jeong-Hwan Kim, Hassan Ashktorab, Duane Smoot, Seon-Young Kim, Chan Choi, Gou Young Koh and Dae-Sik Lim

Pulmonary pericytes regulate lung morphogenesis

Katsuhiro Kato, Rodrigo Diéguez-Hurtado, Do Young Park, Seon Pyo Hong, Sakiko Kato-Azuma, Susanne Adams, Martin Stehling, Britta Trappmann, Jeffrey L. Wrana, Gou Young Koh & Ralf H. Adams 

Myocardial angiopoietin-1 controls atrial chamber morphogenesis by spatiotemporal degradation of cardiac jelly

Kyun HooKim, Yoshikazu Nakaoka, Hellmut G. Augustin & Gou YoungKoh

Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality 

Il-Kug Kim, Kangsan Kim, , Eunhyeong Lee, Dong Sun Oh, Chan Soon Park, Seongyeol Park , Jee Myung Yang, Ju-Hee Kim, Hyung-Seok Kim, David T. Shima, Jeong Hoon Kim, Seok Ho Hong, Young Hyun Cho, Young Hoon Kim, Jong Bae Park, Gou Young Koh, Young Seok Ju, Heung Kyu Lee, Seungjoo Lee & Injune Kim 

Organ-specific lymphatic vasculature: From development to pathophysiology 

Tatiana V. Petrova & Gou Young Koh


Impaired angiopoietin/Tie2 signaling compromises Schlemm’s canal integrity and induces glaucoma

Jaeryung Kim, Dae-Young Park, Hosung Bae, Do Young Park, Dongkyu Kim, Choong-kun Lee, Sukhyun Song, Tae-Young Chung, Dong Hui Lim, Yoshiaki Kubota, Young-Kwon Hong, Yulong He, Hellmut G. Augustin, Guillermo Oliver & Gou Young Koh

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

Jongshin Kim, Yoo Hyung Kim, Jaeryung Kim, Do Young Park, Hosung Bae, Da-Hye Lee, Kyun Hoo Kim, Seon Pyo Hong, Seung Pil Jang, Yoshiaki Kubota, Young-Guen Kwon, Dae-Sik Lim & Gou Young Koh

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

Hellmut G. Augustin & Gou Young Koh

Plastic roles of pericytes in the blood–retinal barrier

Do Young Park, Junyeop Lee, Jaeryung Kim, Kangsan Kim, Seonpyo Hong, Sangyeul Han, Yoshiaki Kubota, Hellmut G. Augustin, Lei Ding, Jin Woo Kim, Hail Kim, Yulong He, Ralf H. Adams & Gou Young Koh 

VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis

Jeon Yeob Jang, Sung Yong Choi, Intae Park, Do Young Park, Kibaek Choe, Pilhan Kim, Young Keum Kim, Byung-Joo Lee, Masanori Hirashima, Yoshiaki Kubota, Jeong-Won Park, Sheue-Yann Cheng, Andras Nagy, Young Joo Park, Kari Alitalo, Minho Shong & Gou Young Koh

Generation of PDGFRα+ cardioblasts from pluripotent stem cells

Seon Pyo Hong, Sukhyun Song, Sung Woo Cho, Seungjoo Lee, Bong Ihn Koh, Hosung Bae, Kyun Hoo Kim, Jin-Sung Park, Hyo-Sang Do, Ilkyun Im, Hye Jin Heo, Tae Hee Ko, Jae-Hyeong Park, Jae Boum Youm, Seong-Jin Kim, Injune Kim, Jin Han, Yong-Mahn Han & Gou Young Koh 

Tumor angiogenesis: Taking aim at Sox18

Injune Kim, Gou Young Koh


Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

Man Chu, Taotao Li, Bin Shen, Xudong Cao, Haoyu Zhong, Luqing Zhang, Fei Zhou, Wenjuan Ma, Haijuan Jiang, Pancheng Xie, Zhengzheng Liu, Ningzheng Dong, Ying Xu, Yun Zhao, Guoqiang Xu, Peirong Lu, Jincai Luo, Qingyu Wu, Kari Alitalo, Gou Young Koh, Ralf H Adams & Yulong He

Carbohydrate-binding protein CLEC14A regulates VEGFR-2– and VEGFR-3–dependent signals during angiogenesis and lymphangiogenesis

Sungwoon Lee, Seung-Sik Rho, Hyojin Park, Jeong Ae Park, Jihye Kim, In-Kyu Lee, Gou Young Koh, Naoki Mochizuki, Young-Myeong Kim & Young-Guen Kwon

Normalization of tumor vessels by Tie2 activation and Ang2 inhibition enhances drug delivery and produces a favorable tumor microenvironment

Jin-SungPark, Il-Kug Kim, Sangyeul Han, Intae Park, Chan Kim, Jeomil Bae, Seung Ja Oh, Seungjoo Lee, Jeong Hoon Kim, Dong-Cheol Woo, Yulong He, Hellmut G. Augustin, Injune Kim, Doheon Lee & Gou Young Koh

Tie1 controls angiopoietin function in vascular remodeling and inflammation

Emilia A. Korhonen, Anita Lampinen, Hemant Giri, Andrey Anisimov, Minah Kim, Breanna Allen, Shentong Fang, Gabriela D’Amico, Tuomas J. Sipilä, Marja Lohela, Tomas Strandin, Antti Vaheri, Seppo Ylä-Herttuala, Gou Young Koh, Donald M. McDonald, Kari Alitalo & Pipsa Saharinen

Amelioration of sepsis by TIE2 activation–induced vascular protection

Sangyeul Han, Seung-Jun Lee, Kyung Eun Kim, Hyo Seon Lee, Nuri Oh, Inwon Park, Eun Ko, Seung Ja Oh, Yoon-Sook Lee, David Kim, Seungjoo Lee, Dae Hyun Lee, Kwang-Hoon Lee, Su Young Chae, Jung-Hoon Lee, Su-Jin Kim, Hyung-Chan Kim, Seokkyun Kim, Sung Hyun Kim, Chungho Kim, Yoshikazu Nakaoka, Yulong He, Hellmut G. Augustin, Junhao Hu, Paul H. Song, Yong-In Kim, Pilhan Kim, Injune Kim & Gou Young Koh

Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

Yunho Kim, Hye Jin Nam, Junyeop Lee, Do Young Park, Chan Kim, Young Suk Yu, Dongha Kim, Se Won Park, Jinhyuk Bhin, Daehee Hwang, Ho Lee, Gou Young Koh & Sung Hee Baek 


Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

Maike Frye, Martina Dierkes, Verena Küppers, Matthias Vockel, Janina Tomm, Dagmar Zeuschner, Jan Rossaint, Alexander Zarbock, Gou Young Koh, Kevin Peters, Astrid Fee Nottebaum & Dietmar Vestweber

AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation

Hyojin Park, Sungwoon Lee, Pravesh Shrestha, Jihye Kim, Jeong Ae Park, Yeongrim Ko, Young Ho Ban, Dae-Young Park, Sang-Jun Ha, Gou Young Koh, Victor Sukbong Hong, Naoki Mochizuki, Young-Myeong Kim, Weontae Lee & Young-Guen Kwon

Intravital imaging of intestinal lacteals unveils lipid drainage through contractility

Kibaek Choe, Jeon Yeob Jang, Intae Park, Yeseul Kim, Soyeon Ahn, Dae-Young Park, Young-Kwon Hong, Kari Alitalo, Gou Young Koh & Pilhan Kim

Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion 

Ki Yong Hong, Hosung Bae, Intae Park, Dae-Young Park, Kyun Hoo Kim, Yoshiaki Kubota, Eui-Sic Cho, Hail Kim, Ralf H. Adams, Ook-Joon Yoo & Gou Young Koh

~2014 (Selected publications)

Lymphatic regulator PROX1 determines Schlemm’s canal integrity and identity

Dae-Young Park, Junyeop Lee, Intae Park, Dongwon Choi, Sunju Lee, Sukhyun Song, Yoonha Hwang, Ki Yong Hong, Yoshikazu Nakaoka, Taija Makinen, Pilhan Kim, Kari Alitalo, Young-Kwon Hong & Gou Young Koh

Vascular RhoJ Is an effective and selective target for tumor angiogenesis and vascular disruption

Chan Kim, Hanseul Yan,g Yoko Fukushima, Phei Er Saw, Junyeop Lee, Jin-Sung Park, Intae Park, Jinmyung Jung, Hiroshi Kataoka, Doheon Lee, Won Do Heo, Injune Kim, Sangyong Jon, Ralf H. Adams, Shin-Ichi Nishikawa, Akiyoshi Uemura & Gou Young Koh

Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis

Seung-Hun Lee, Sungsu Lee, Hanseul Yang, Sukhyun Song, Kangsan Kim, Thomas L. Saunders, Jeong K. Yoon, Gou Young Koh & Injune Kim

Angiopoietin-1 suppresses choroidal neovascularization and vascular leakage

Junyeop Lee, Dae-Young Park, Do Young Park, Intae Park, Woohyok Chang, Yoshikazu Nakaoka, Issei Komuro, Ook-Joon Yoo & Gou Young Koh

Inflammation-associated lymphangiogenesis: a double-edged sword?

Honsoul Kim, Raghu P. Kataru & Gou Young Koh

Angiopoietin-1 guides directional angiogenesis through Integrin avb5 signaling for recovery of ischemic retinopathy

Junyeop Lee, Kyung Eun Kim, Dong-Kyu Choi, Jeon Yeob Jang, Ji-Jung Jung, Hiroshi Kiyonari, Go Shioi, Woohyok Chang, Toshio Suda, Naoki Mochizuki, Yoshikazu Nakaoka, Issei Komuro, Ook-Joon Yoo & Gou Young Koh

VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy

Minah Kim, Hyeung Ju Park, Jae Won Seol, Jeon Yeob Jang, Young-Suk Cho, Kyu Rae Kim, Youngsok Choi, John P. Lydon, Francesco J. DeMayo, Masabumi Shibuya, Napoleone Ferrara, Hoon-Ki Sung, Andras Nagy, Kari Alitalo & Gou Young Koh

T Lymphocytes negatively regulate lymph node lymphatic vessel formation

Raghu P. Kataru, Honsoul Kim, Cholsoon Jang, Dong Kyu Choi, Bong Ihn Koh, Minah Kim, Sudheer Gollamudi, Yun-Keun Kim, Seung-Hyo Lee & Gou Young Koh

CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche

Minah Kim, Young Jun Koh, Kyung Eun Kim, Bong Ihn Koh, Do-Hyun Nam, Kari Alitalo, Injune Kim & Gou Young Koh

Double antiangiogenic protein, DAAP, targeting VEGF-A and Angiopoietins in tumor angiogenesis, metastasis, and vascular leakage

Young Jun Koh, Hak-Zoo Kim, Seong-Ik Hwang, Jeung Eun Lee, Nuri Oh, Keehoon Jung, Minah Kim, Kyung Eun Kim, Homin Kim, Nam-Kyu Lim, Choon-Ju Jeon, Gyun Min Lee, Byeong Hwa Jeon, Do-Hyun Nam, Hoon Ki Sung, Andras Nagy, Ook Joon Yoo & Gou Young Koh