New paper for a multifunctional peptide Apelin is published online.
April 07, 2022
New review paper for Dual-blocking antibody against VEGF-A and angiopoietin-2 is now online.
April 07, 2022
New review paper for antiangiogenesis is now online.
February 07, 2022
New paper for the nasal mucosal immunity against SARS-CoV-2 is published.
July 02, 2021
Winners of IBS·Art in Science 2020
Confocal fluorescence microscopy of the stained mouse embryo blood vesses 10.5 days after fertilization
Dr. Seon-Pyo Hong
Flowers covered with grass
Within the villi of the mouse small intestine, the interaction among the cells in the lacteal and the surrounding tissue has been photographed
Dr. Ji Hoon Ahn
Red alert : COVID-19
Infected epithelial cells collected from the nose of a COVID-19 patient that underwent fluorescent staining using a virus-specific protein antibody.
Director Gou Young Koh was selected as the Scientist of the Year 2020 by science journalists!
New paper for identifying new subsets of gut connective cells is now online.
August 18, 2020
A team of scientists led by Gou Young Koh at the IBS Center for Vascular Research have identified new subsets of gut connective cells, which are crucial for lymphatic growth. Their new findings have been reported in the journal Nature Communications.
Seon Pyo Hong, Myung Jin Yang, Hyunsoo Cho, Intae Park, Hosung Bae, Kibaek Choe, Sang Heon Suh, Ralf H. Adams, Kari Alitalo, Daesik Lim, Gou Young Koh. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi. Nature Communications (2020). DOI: 10.1038/s41467-020-17886-y
New paper! Angpt2 is a key adipokine driving lipid accumulation into the SAT.
June 15, 2020
Scientists at IBS Center for Vascular Research have reported Angpt2 as a key adipokine driving lipid accumulation into the SAT. This is through endothelial FA transport mediated by Angpt2- integrin α5β1 signaling, which prevents ectopic fat accumulation into endocrine organs, and thus prevents insulin resistance. Their findings have been reported in the journal Nature Communications on June 12.
Hosung Bae, Ki Yong Hong, Choong-kun Lee, Cholsoon Jang, Seung-Jun Lee, Kibaek Choe, Stefan Offermanns, Yulong He, Hyuek Jong Lee, and Gou Young Koh. Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid–induced insulin resistance. Nature Communications (2020)DOI : 10.1038/s41467-020-16795-4
Unveil how stromal cells in the lymph node regulate immune response!
February 07, 2020
IBS Scientists have reported the key signaling pathway governing the integrity of FRCs in modulating immune responses. They found that the Hippo-YAP/TAZ signaling pathway plays dominant roles in regulating the immune-responsive features of FRCs. They confirmed through genetically modified mouse models that deletion or hyperactivation of YAP/TAZ led to impaired differentiation and maintenance of FRCs to varying degrees, leading to disrupted formation and compartmentalization of LNs and their immune responsiveness.
Sung Yong Choi, Hosung Bae, Sun-Hye Jeong, Intae Park, Hyunsoo Cho, Seon Pyo Hong, Da-Hye Lee, Choong-kun Lee, Jin-Sung Park, Sang Heon Suh, Jeongwoon Choi, Jeon Yeob Jang, Lucas Onder, Jeong Hwan Moon, Han-Sin Jeong, Ralf H. Adams, Jin-Man Kim, Burkhard Ludewig, Joo-Hye Song, Dae-Sik Lim, and Gou Young Koh. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nature Communications (2020)DOI : https://doi.org/10.1038/s41467-020-14293-1
New paper for answering the key question about brain clearance is published!
July 25, 2019
Scientists led by Dr. Gou Young Koh at the Institute for Basic Science (IBS) revealed an accurate route of cerebrospinal fluid drainage and characterized meningeal lymphatic vessels at the skull base for the first time, in the July 24 Nature.
Therapies targeting abnormally accumulated protein such as beta-amyloid for patients with Alzheimer’s disease are currently being actively developed. By drawing the clear roadmap of exit route for macromolecules leaving the brain found by this study, researchers may be able to find a link between dysfunction of this system and the accumulation of toxic metabolites within the brain. Dr. Koh says, “It definitely warrants more extensive investigation of meningeal lymphatic vessels in patients with age-related neurodegenerative disease such as Alzheimer’s disease prior to clinical investigation.”
Ji Hoon Ahn, Hyunsoo Cho, Jun-Hee Kim, Shin Heun Kim, Je-Seok Ham, Intae Park, Sang Heon Suh, Seon Pyo Hong, Joo-Hye Song, Young-Kwon Hong, Yong Jeong, Sung-Hong Park, and Gou Young Koh. Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid. Nature (2019)DOI : https://doi.org/10.1038/s41586-019-1419-5
Tumor metastasis to lymph node requires metabolic reprogramming to use fatty acid as a fuel.
February 08, 2019
Researchers at IBS Center for Vascular Research discovered the mechanism how metastatic tumor cells grow in lymph nodes. The study revealed that tumor cells undergo a metabolic reprogramming toward fatty acid oxidation (FAO). Transcriptional co-acitvator YAP, potentially activated by accumulated bile acids, was selectively activated in LN metastatic tumors, leading to the up-regulation of genes in the FAO signaling pathway. This study propose that inhibition of FAO or YAP signaling to prevent the metabolic adaptation of metastatic tumors offers a potential therapeutic strategy for mitigating tumor LN metastasis. This study was published in Science at February 8 2019.Choong-kun Lee, Seung-hwan Jeong, Cholsoon Jang, Hosung Bae, Yoo Hyung Kim, Intae Park, Sang Kyum Kim, Gou Young Koh. Tumor metastasis to lymph node requires YAP-dependent metabolic adaptation. SCIENCE 08 Feb 2019 : 644-649DOI: 10.1126/science.aav0173
Congratulations to Dr. Jin-Sung Park for winning 2018 Agarwal Award!
August 13, 2018
Congratulations! Director Gou Young Koh was awarded the 28th Ho-Am Prize in Medicine.
June 25, 2018
The 28th Ho-Am Prize Presentation Ceremony was held on June 1st at the Ho-Am Art Hall in Seoul. The winner of this year is Professor Hee Oh of Yale University (Science), Professor Nam-Gyu Park of Sungkyunkwan University (Engineering), Distinguished Professor Gou Young Koh of KAIST (Medicine), Opera Singer Kwangchul Youn (The Arts) and Sister Carla Kang (Community Sevice). Each of them received a gold medal and 300 million won of prize. The ceremony was attended by more than 500 people including Professor Tim Hunt, Nobel Prize winner in 2001, Italian Ambassador to Korea Marco della Seta, Nak-in Sung SNU president, and Sung-chul Shin, president of KAIST.
Director Gou Young Koh has been awarded the 28th Ho-Am Prize in Medicine, which is awarded annually to those who have made distinguished contributions in the field of medicine, physiology, and pharmacology.
Hyunsoo Cho received Basic Medical Research Award for Young Scientist.
May 18, 2018.
Hyunsoo Cho, a Ph.D. student from IBS Center for Vascular Research received Basic Medical Research Award for Young Scientist for his work ‘The role of upfront autologous stem cell transplantation in high-risk younger patients with primary central nervous system lymphoma’ published in British Journal of Haematology.
The prize is awarded by Korean Medical Association in order to encourage basic medical research through the award of young physician-scientist who have outstanding research achievements. The trophy and five-million-won prize were given at the 70th Korean Medical Association council meeting held at The K-hotel Seoul on April 22, 2018
Hyunsoo Cho was named for the Young Investigator Conference Scholarships Award at 2018 Lymphatics Gordon Research Conference.
March 23, 2018
Hyunsoo Cho, a Ph.D. student at IBS Center for Vascular Research was named for the Young Investigator Conference Scholarships Award for his work in ‘Yap/Taz negatively regulates Prox1 during developmental and pathologic lymphangiogenesis’.
Dr. Seon Pyo Hong won Best Post Award at 2018 Lymphatics Gordon Research Conference.
March 23, 2018
Seon Pyo Hong, a post-doctoral fellow of IBS Center for Vascular Research received Best Post Award at the conference for his work in ‘Surrounding PDGFRβ+ stromal cells regulate lacteal integrity through Yap/Taz-induced VEGF-C secretion in intestinal villi’
2018 Lymphatics Gordon Research Conference (GRC) was successfully held at Lucca, Italy.
March 23, 2018
The 2018 Lymphatics Gordon Research Conference (GRC), chaired by IBS Center for Vascular Research Director Gou Young Koh and Dr. Mihaela Skobe (Icahn School of Medicine at Mount Sinai, New York, NY, USA) was successfully held bringing leader scientists working on lymphatics together from March 11-16. 2018 at Lucca, Italy. This meeting focused on finding out new factors for regulating lymphangiogenesis and lymphatic integrity, as well as to treat pathologies involving the lymphatic system including the role of brain lymphatics in neurodegenerative disease.
A review article for organ-specific lymphatic vasculature was published in Journal of Experimental Medicine.
December 15, 2017
This review summarize the most recent findings of organotypic differentiation of lymphatic endothelial cells in terms of their distinct (patho)physiological functions in skin, lymph nodes, small intestine, brain, and eye. This review also discuss recent advances in the understanding of the heterogeneity of lymphatic vessels with respect to the organ-specific functional and molecular specialization of lymphatic endothelium, such as the hybrid blood-lymphatic identity of Schlemm’s canal, functions of intestinal lymphatics in dietary fat uptake, and discovery of meningeal lymphatic vasculature and perivascular brain lymphatic endothelial cells.Tatiana V. Petrova and Gou Young Koh. Organ-specific lymphatic vasculature: From development to pathophysiology. Journal of Experimental Medicine (2018) 215 (1): 35–49.DIO: https://doi.org/10.1084/jem.20171868
YAP/TAZ study in angiogenesis was selected as 2017 BRIC TOP5 research.
December 15, 2017
The YAP/TAZ study by Kim et al. (Journal of Clinical Investigation 2017) was selected as 2017 BRIC TOP5 research in biomedical field.
Research Article : YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. Kim J, Kim YH, Kim J, Park DY, Bae H, Lee DH, Kim KH, Hong SP, Jang SP, Kubota Y, Kwon YG, Lim DS, Koh GY. J Clin Invest. 2017.
New paper for Angiopoietin/Tie2 signaling in maintaining Schlemm’s canal integrity
September 19, 2017
Researchers at IBS Center for Vascular Research identified a critical role of angiopoietin/Tie2 signaling in maintaining Schlemm’s canal integrity. Impairment of this signaling could be involved in the pathogenesis of primary open-angle glaucoma, the most common form of glaucoma. Of special note, intraocular administration of Tie2 activator reduces the elevated intraocular pressure and recovers regressed Schlemm’s canal in glaucoma animal model, suggesting one of therapeutic options for glaucoma. This study was published in Journal of Clinical Investigation at September 18 2017 and highlighted as a Cover Story.Jaeryung Kim, Dae-Young Park, Hosung Bae, Do Young Park, Dongkyu Kim, Choong-kun Lee, Sukhyun Song, Tae-Young Chung, Dong Hui Lim, Yoshiaki Kubota, Young-Kwon Hong, Yulong He, Hellmut G. Augustin, Guillermo Oliver & Gou Young Koh. Impaired angiopoietin/Tie2 signaling compromises Schlemm’s canal integrity and induces glaucoma. Journal of Clinical Investigation (2017)DOI : https://doi.org/10.1172/JCI94668
YAP/TAZ : A Key Regulator in Physiological Angiogenesis
August 29, 2017
Researchers at IBS Center for Vascular Research discovered a key regulator of physiological angiogenesis. The study revealed that YAP and TAZ, an end effector of Hippo signaling, are critical for sprouting angiogenesis, vascular barrier formation, and maturation. These findings extend the understanding in the transcriptional regulation of vessel sprouting and barrier maturation, and suggest the new therapeutic options for pathologic angiogenesis, such as age-related macular degeneration. This study was published in Journal of Clinical investigation at August 14 2017 and highlighted as a Scientific Show Stopper.Jongshin Kim, Yoo Hyung Kim, Jaeryung Kim, Do Young Park, Hosung Bae, Da-Hye Lee, Kyun Hoo Kim, Seon Pyo Hong, Seung Pil Jang, Yoshiaki Kubota, Young-Guen Kwon, Dae-Sik Lim & Gou Young Koh. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. Journal of Clinical Investigation (2017)DOI : https://doi.org/10.1172/JCI93825
A review article for organotypic vasuclature was published in Science.
August 04, 2017
A review article for organotypic vasuclature just published in Science.
This review summarizes recent progress in the understanding of organotypic vascular differentiation and function.Hellmut G. Augustin & Gou Young Koh. Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology. Science (2017)DOI: 10.1126/science.aav0173
A potential therapeutic target for thyroid diseases
June 22, 2017
Researchers at IBS Center for Vascular Research clarified the molecular mechanism to explain how the thyroid and surrounding vascular system change in the most common form of hyperthyroidism. These findings provide a potential therapeutic target for thyroid diseases. The study was highlighted as a cover in EMBO Molecular Medicine journal.Jeon Yeob Jang, Sung Yong Choi, Intae Park, Do Young Park, Kibaek Choe, Pilhan Kim, Young Keum Kim, Byung-Joo Lee, Masanori Hirashima, Yoshiaki Kubota, Jeong-Won Park, Sheue-Yann Cheng, Andras Nagy, Young Joo Park, Kari Alitalo, Minho Shong & Gou Young Koh. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis. EMBO Molecular Medicine (2017)DOI: https://doi.org/10.15252/emmm.201607341
Dr. Jin-Sung Park received Enzynomics Best Ph.D. Thesis Award.
February 28, 2017
Dr. Jin-Sung Park from IBS Center for Vascular Research received "Enzynomics Best Ph.D. Thesis Award".
"Enzynomics Best Ph.D. Thesis Award" is given annually by the College of Life Science and Bioengineering in KAIST. Recipients are selected by the committee among graduate students of College of Life Science and Bioengineering, who published outstanding and high-impact Ph.D. thesis during their Ph.D. course. Winners are given trophy and 1,500,000 prize.
Mi Jung Kim won Grand Prize in 13th International Biomicroscope Photo Exhibition.
January 16, 2017
13th International Biomicroscope Photo Exhibition Award
Title : Lonely Pink Dolphin
Winner : Mi Jung Kim, Grand Prize in General Section
Photographic Microscope : Transmission Electron Microscope (6500x)
This photograph shows that the retinal tissue of the mouse which was chemically immobilized and then ultra-sliced cut and observed with a transmission electron microscope (120 KV). While observing the image, She found a resemblance to the face of a dolphin in a part of the cell's vacuole. The retinal pigment of the vacuole is similar to the eye of a dolphin, and the vacuole membrane extends from the face of the dolphin to the tail.
New paper - Develop a new therapeutic approach to normalize tumor vessels!
December 13, 2016
Researchers at IBS Center for Vascular Research have discovered a treatment to normalize tumor vessels. Their antibody ABTAA (Ang2-Binding and Tie2-Activating Antibody), which was also highlighted as an anti-sepsis antibody, reduced tumor volume and improved the delivery of anti-cancer drugs.
Researchers tested ABTAA in mice with three different types of tumors that show high levels of Ang2: glioma, lung carcinoma and breast cancer. They also compared the effect of ABTAA with ABA, another antibody that blocks Ang2 but misses the Tie2 activating properties. In all three cases, ABTAA was superior to ABA in inducing tumor vessel normalization, which led to a better delivery of the anti-cancer drugs into the tumor core region. Therefore, ABTAA reduced glioma growth, lung and breast cancer progression in mice.Jin-SungPark, Il-Kug Kim, Sangyeul Han, Intae Park, Chan Kim, Jeomil Bae, Seung Ja Oh, Seungjoo Lee, Jeong Hoon Kim, Dong-Cheol Woo, Yulong He, Hellmut G. Augustin, Injune Kim, Doheon Lee & Gou Young Koh. Normalization of tumor vessels by Tie2 activation and Ang2 inhibition enhances drug delivery and produces a favorable tumor microenvironment. Cancer Cell (2016)DOI: https://doi.org/10.1016/j.ccell.2016.10.018
Director Koh has been appointed as 'External Scientific Member of the MPI'.
December 13, 2016
Director Koh has recently been appointed as ‘External Scientific Member of the Max Plank Institute for Molecular Medicine in Munster’
New paper - Researchers develop a new therapeutic approach to sepsis!
December 13, 2016
IBS Researchers have conducted a treatment for sepsis, which is difficult to treat and life-threatening due to components such as vascular disintegration and leakage. The authors developed an antibody that stimulates TIE2, a cell surface receptor tyrosine kinase that is highly expressed on endothelial cells. The antibody, called ABTAA, which binds to ANG2 and activates TIE2 integrates the endothelium to fortify intercellular junctions and to reduce the expression of adhesion molecules for leukocytes. As a result, activated TIE2 promotes barrier defense against vascular leakage and counteracts vascular inflammation. This new therapeutic approach greatly increases the survival rate during sepsis, by protecting the vascular walls and blunting septic damage. The study was highlighted as a focus article and also selected as a cover in the leading biomedical journal, Science Translational Medicine.Sangyeul Han, Seung-Jun Lee, Kyung Eun Kim, Hyo Seon Lee, Nuri Oh, Inwon Park, Eun Ko, Seung Ja Oh, Yoon-Sook Lee, David Kim, Seungjoo Lee, Dae Hyun Lee, Kwang-Hoon Lee, Su Young Chae, Jung-Hoon Lee, Su-Jin Kim, Hyung-Chan Kim, Seokkyun Kim, Sung Hyun Kim, Chungho Kim, Yoshikazu Nakaoka, Yulong He, Hellmut G. Augustin, Junhao Hu, Paul H. Song, Yong-In Kim, Pilhan Kim, Injune Kim & Gou Young Koh. Amelioration of sepsis by TIE2 activation–induced vascular protection. Science Translational Medicine (2016)DOI: 10.1126/scitranslmed.aad9260
Research Grant Award from Human Frontier Science Program
March 31, 2016
Director Gou Young Koh has been awarded a research grant from the Human Frontier Science Program (HFSP). This project presented by a team of three – Burkhard Ludewig, Gou Young Koh, Seok-Hyun Yun - aims at understanding the role of newly formed lymph node structures in tumor progression and immunity. Professor Ludewig is an essential biologist from Switzerland and Professor Yun is an expertise in bioengineering from the USA. On March 18, HFSP announced the winners of the 2016 awards for Research Grants. The Board of Trustees approved the award for a period of three years for our collaborative team, which was among the successful candidates in this highly competitive field. Our application was ranked 2nd among 25 awards made from 65 full applications for Program Grants (from an initial total of 672 letters of intent).* HFSP is an international program of research support implemented by the International Human Frontier Science Program Organization (HFSPO) based in Strasbourg, France. It aims to promote intercontinental collaboration and training in cutting-edge, interdisciplinary research focused on the life sciences.
Dr. Dae Young Park won the Young Investigator Award at the 2015 Annual Meeting of VSMO.
October 17, 2015
Dae Young Park, a Postdoctoral fellow was named for the Young Investigator Award named at The 2015 Annual Meeting of Vascular Science and Medicine Organization for his work in”Angiopoietin/Tie 2 signaling contributes to the development of lymphatic phenotype of Schlemm’s canal mediated by Prox1”. The Annual Meeting of Vascular Science and Medicine Organization was started by the vascular research society composed of leading vascular researchers, settling international networks for basic and clinical studies since 2000, contributing to advance in vascular biology research and public health.
Jaeryung Kim and Sang Heon Suh won Awards at The 10th World Congress for Microcirculation.
September 27, 2015
Jaeryung Kim and Sang Heon Suh were each named for Travel Award, and Best Poster Award at the 10th World Congress for Microcirculation. Jaeryung Kim, a second-year PhD. student was named for the Travel Award for his work in “The role of limbal lymphatics in corneal fluid homeostasis and proper pathogen clearance.” Sang Heon Suh, also a second-year PhD. student was named for the Best Poster Award for his work in “RhoJ is an effectible and selectable target of antiangiogenic cancer therapy.”
IBS Launches its First Center in the Field of Basic Medical Sciences.
August 26, 2015
IBS Launches its First Center in the Field of Basic Medical Sciences.
KAIST Professor Gou Young Koh begins his research in July as a director of the IBS Center for Vascular Research. Gou Young Koh, a distinguished professor from the Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), has been selected as a director at the Institute for Basic Science (IBS).
Director Koh, a world-renowned pioneer in the field of Vascular Biology, begins his research from July 1 as a director of the Center for Vascular Research.