An article titled “CSF clearance through arachnoid fenestrations to olfactory meningeal lymphatics” has recently been published in Cell

A team led by Dr. Gou Young Koh and Dr. Seon Pyo Hong has found tiny openings in the arachnoid membrane near the olfactory bulbs that let cerebrospinal fluid (CSF) drain directly into lymphatic vessels, which cross the skull's cribriform plate and connect to nasal lymphatics leading to the neck's lymph nodes. Similar structures were confirmed in monkeys.

This drainage route weakens with age, contributing to reduced CSF clearance linked to Alzheimer's and other neurodegenerative diseases. Remarkably, a single intranasal VEGF-C gene therapy fully restored lymphatic function and CSF outflow in aged mice — pointing to a potential treatment strategy.

Prof. Won-Suk Chung of IBS Center for Vascular Research Receives Grand Prize at 20th Life's Mystery Award 

Established in 2006 by the Bioethics Committee of the Catholic Archdiocese of Seoul, the award honors individuals and organizations that uphold the dignity of human life. Prof. Chung was recognized for his pioneering contributions at the intersection of neuroimmunology and neuroscience.

His research has demonstrated that astrocytes and microglia play key roles in remodeling neural circuits and maintaining brain homeostasis, and that glial dysfunction is linked to conditions such as epilepsy, stroke, depression, and Alzheimer's disease — pointing toward new therapeutic possibilities.

The award ceremony will be held on June 9 at the Seoul St. Mary's Hospital Campus of The Catholic University of Korea.

Nasal ciliated cells are primary targets for SARS-CoV-2 replication in early stage of COVID 19

Lymphatic vessel in lacteal